Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Naquotinib mesylate (ASP8273 (mesylate)) 是一种口服的、突变体选择性和不可逆的 EGFR 抑制剂,对 EGFR 突变体和 EGFR 的 IC50值分别为8-33和230 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 497 | 5日内发货 | ||
5 mg | ¥ 869 | 5日内发货 | ||
100 mg | ¥ 7,890 | 6-8周 |
Naquotinib mesylate 的其他形式现货产品:
产品描述 | Naquotinib mesylate (ASP8273 (mesylate)) is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFR mutants and EGFR). |
靶点活性 | EGFR:230 nM |
体外活性 | In NCI-H1650 (del ex19), Naquotinib inhibits cell growth with an IC50 value of 70nM while other EGFR-TKIs are only partially effective.Naquotinib selectively inhibits phosphorylation of EGFR and its down-stream signal pathway, ERK and Akt from 10nM in HCC827 and NCI-H1975 while inhibitory effects are only detected at 1000nM in A431[2]. |
体内活性 | In an NCI-H1975 xenograft model, complete regression of tumor is achieved after 14-days of Naquotinib treatment.?Complete regression is maintained in 50% of mice more than 85 days after cessation of Naquotinib treatment[2]. |
别名 | ASP8273 (mesylate) |
分子量 | 658.81 |
分子式 | C31H46N8O6S |
CAS No. | 1448237-05-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12.5 mg/mL (18.97 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5179 mL | 7.5894 mL | 15.1789 mL | 37.9472 mL |
5 mM | 0.3036 mL | 1.5179 mL | 3.0358 mL | 7.5894 mL | |
10 mM | 0.1518 mL | 0.7589 mL | 1.5179 mL | 3.7947 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Naquotinib mesylate 1448237-05-5 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR ErbB-1 ASP8273 (mesylate) Inhibitor ASP8273 ASP 8273 HER1 Epidermal growth factor receptor inhibit Naquotinib Mesylate ASP-8273 Naquotinib inhibitor